Rabbit Polyclonal Antibody to CDCA2

Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates.Walker M.G., Curr. Cancer Drug Targets 1:73-83(2001).Ota T., . Genet. 36:40-45(2004).Olsen J.V., Cell 127:635-648(2006).