Rabbit Polyclonal Antibody to PIP5K

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes.Ota T., Nat. Genet. 36:40-45(2004).Sbrissa D., J. Biol. Chem. 277:6073-6079(2002).Brill L.M., Anal. Chem. 76:2763-2772(2004).