Rabbit Polyclonal Antibody to SPR1

Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca2+ mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer By similarity.An S., FEBS Lett. 375:121-124(1995).Xu Y., Genomics 35:397-402(1996).King M.M., Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.