Rabbit Polyclonal Antibody to CUTL1

Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator By similarity.Neufeld E.J., Nat. Genet. 1:50-55(1992).Gloeckner G., Genome Res. 8:1060-1073(1998).Rong Zeng W., Gene 241:75-85(2000).