Rabbit Polyclonal Antibody to TAF1

Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Exhibits histone acetyltransferase activity towards histones H3 and H4.Sekiguchi T., Mol. Cell. Biol. 11:3317-3325(1991).Ruppert S., Nature 362:175-179(1993).Nolte D., Proc. Natl. Acad. Sci. U.S.A. 100:10347-10352(2003).