Rabbit Polyclonal Antibody to Adrenergic Receptor alpha-2B

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.Lomasney J.W., Proc. Natl. Acad. Sci. U.S.A. 87:5094-5098(1990).Weinshank R.L., Mol. Pharmacol. 38:681-688(1990).Small K.M., J. Biol. Chem. 276:4917-4922(2001).