Rabbit Polyclonal Antibody to CEBPB

Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Plays an important role in adipose tissue differentiation. Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG) as well as other adipogenesis key player genes. Isoform 3:acts as a dominant negative through heterodimerization with isoform 2.Akira S., EMBO J. 9:1897-1906(1990).Wan D., Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).Deloukas P., Nature 414:865-871(2001).