Rabbit Polyclonal Antibody to Histone H2AX

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.The MGC Project Team; Genome Res. 14:2121-2127(2004).Rogakou E.P., J. Biol. Chem. 273:5858-5868(1998).Rogakou E.P., J. Biol. Chem. 275:9390-9395(2000).