Rabbit Polyclonal Antibody to CTRO

Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.Nagase T., DNA Res. 6:63-70(1999).Scherer S.E., Nature 440:346-351(2006).Gruneberg U., J. Cell Biol. 172:363-372(2006).