Rabbit Polyclonal Antibody to Sodium Channel-pan

This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na+ channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels.Sebastian K.G. Maier, Circulation, Mar 2004; 109: 1421 - 1427. T.R. Cummins, Neurology, Jan 2003; 60: 224 - 229. Christopher A. Ahern, Circ. Res., May 2005; 96: 991 - 998. Jyoti Dhar Malhotra, Circulation, Mar 2001; 103: 1303 - 1310.