Rabbit Polyclonal Antibody to Retinoic Acid Receptor β

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.Reuben Lotan, N. Engl. J. Med., May 1995; 332: 1405 - 1411. Andrew Yen, Mol. Pharmacol., Dec 2004; 66: 1727 - 1737. K Swisshelm, Cell Growth Differ., Feb 1994; 5: 133. F Aoudjit, Cell Growth Differ., May 1995; 6: 515.