Rabbit Polyclonal Antibody to NKX3.1

Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.Cai Bowen, Cancer Res., Jan 2007; 67: 455 - 464. Xiang Li, Mol. Cell. Biol., Apr 2006; 26: 3008 - 3017. Ekatherine Asatiani, Cancer Res., Feb 2005; 65: 1164 - 1173. Carlise R. Bethel, Cancer Res., Nov 2006; 66: 10683 - 10690.