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Western blot analysis of extracts from HeLa cells, using Collagen IV antibody P41792.

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Collagen IV antibody P41792.

Rabbit Polyclonal Antibody to Collagen IV

货号：
P41792
别名：
COL4A1 NC1 domain; COLLAGEN OF BASEMENT MEMBRANE; ALPHA-1 CHAIN ARRESTEN; alpha 1 type IV collagen preproprotein; collagen IV alpha-1 polypeptide
产品上架时间：
2024-01-01
应用：
WB,IHC,IF
反应种属：
Human,Mouse
抗体类型：
Primary antibody
Swissprot：
P02462
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥1980

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Description
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin

Description

References
Mary K. Chelberg, Cancer Res., Sep 1989; 49: 4796 - 4802 Patricia L. Graham, J. Cell Biol., Jun 1997; 137: 1171 PJ Lein, J. Cell Biol., Apr 1991; 113: 417 EC Tsilibary, J. Biol. Chem., Dec 1988; 263: 19112 - 19118.

Specification
Aliases	COL4A1 NC1 domain; COLLAGEN OF BASEMENT MEMBRANE; ALPHA-1 CHAIN ARRESTEN; alpha 1 type IV collagen preproprotein; collagen IV alpha-1 polypeptide
Entrez GeneID	1282;
Swissprot	P02462
WB Predicted band size	160kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Synthesized peptide derived from human Collagen IV.
Formulation	Purified antibody in PBS with 0.05% sodium azide.