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Rabbit Polyclonal Antibody to APLF (Ab-116)

Western blot analysis of extracts from HT-29 cells, using APLF (Ab-116) antibody P41744.

Western blot analysis of extracts from COS7 cells (Lane 2), using APLF (Ab-116) antiobdy P41744. The lane on the left is treated with systhesized peptide.

Immunohistochemistry analysis of paraffin-embedded human brain tissue using APLF (Ab-116) antibody P41744.

Rabbit Polyclonal Antibody to APLF (Ab-116)

货号：
P41744
别名：
APFL; aprataxin and PNK-like factor; C2orf13; Xip1;
产品上架时间：
2024-01-01
应用：
WB,IHC
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
Q8IW19
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥1980

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Rabbit Polyclonal Antibody to APLF (Ab-116)

Description
Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage.Saunders W.S., J. Cell Sci. 104:573-582(1993).Ye Q., J. Biol. Chem. 271:14653-14656(1996).Ye Q., J. Biol. Chem. 272:14983-14989(1997).

Description

Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage.Saunders W.S., J. Cell Sci. 104:573-582(1993).Ye Q., J. Biol. Chem. 271:14653-14656(1996).Ye Q., J. Biol. Chem. 272:14983-14989(1997).

Specification
Aliases	APFL; aprataxin and PNK-like factor; C2orf13; Xip1;
Entrez GeneID	200558;
Swissprot	Q8IW19
WB Predicted band size	57kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized non-phosphopeptide derived from human APLF around the phosphorylation site of serine 116 (R-N-S(p)-Q-V).
Formulation	Purified antibody in PBS with 0.05% sodium azide.