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Western blot analysis of extracts from MCF-7 cells, using PEK/PERK (Ab-981) antibody P41724.

Western blot analysis of extracts from JK cells (Lane 2), using PEK/PERK (Ab-981) antiobdy P41724. The lane on the left is treated with synthesized peptide.

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using PEK/PERK (Ab-981) antibody P41724.

Rabbit Polyclonal Antibody to PEK/PERK (Ab-981)

货号：
P41724
别名：
E2AK3; EC 2.7.11.1; EIF2AK3; Eukaryotic translation initiation factor 2-alpha kinase 3 precursor; HsPEK
产品上架时间：
2024-01-01
应用：
WB,IHC,IF
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
Q9NZJ5
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥1980

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Rabbit Polyclonal Antibody to PEK/PERK (Ab-981)

Description
Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) By similarity

References
Shi Y., J. Biol. Chem. 274:5723-5730(1999) Sood R., Biochem. J. 346:281-293(2000) Delepine M., Nat. Genet. 25-406-409(2000).

Specification
Aliases	E2AK3; EC 2.7.11.1; EIF2AK3; Eukaryotic translation initiation factor 2-alpha kinase 3 precursor; HsPEK
Entrez GeneID	9451;
Swissprot	Q9NZJ5
WB Predicted band size	125kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthesized non-phosphopeptide derived from human PEK/PERK around the phosphorylation site of threonine 981 (R-H-T(p)-G-Q).
Formulation	Purified antibody in PBS with 0.05% sodium azide.