请登录
搜索 英文站
栏目

提醒成功

请输入手机号/邮箱号
请输入密码

账号密码登录

微信/QQ登录 微信/QQ登录

没有账号? 立即注册

搜索
Western blot analysis of extracts from Jurkat cells, using JAK3 (Ab-785) antibody P41674.
Immunohistochemistry analysis of paraffin-embedded human brain tissue using JAK3 (Ab-785) antiobdy P41674.

Rabbit Polyclonal Antibody to JAK3 (Ab-785)

  • 货号:

    P41674
  • 别名:

    EC 2.7.10.2; JAK-3; JAK3; Janus kinase 3; L-JAK
  • 产品上架时间:

    2024-01-01
  • 应用:

    WB,IHC
  • 反应种属:

    Human
  • 抗体类型:

    Primary antibody
  • Swissprot:

    P52333
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥1980

加入购物车

Rabbit Polyclonal Antibody to JAK3 (Ab-785)

Description

Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.Kawamura M., Proc. Natl. Acad. Sci. U.S.A. 91:6374-6378(1994).Lai K.S., J. Biol. Chem. 270:25028-25036(1995).Grimwood J., Nature 428:529-535(2004).

Specification

Aliases EC 2.7.10.2; JAK-3; JAK3; Janus kinase 3; L-JAK
Entrez GeneID 3718;
Swissprot P52333
WB Predicted band size 125kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Synthesized non-phosphopeptide derived from human JAK3 around the phosphorylation site of tyrosine 785 (S-D-Y(p)-E-L).
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

WB 1/500-1/3000
IHC 1/50-1/100

For Reseach Only

Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation

#P41674