Rabbit Polyclonal Antibody to PAK1/2/3 (Ab-423/402/421)

Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development.Bernadett Boda, J. Neurosci., Dec 2004; 24: 10816 - 10825. Donna L. McPhie, J. Neurosci., Jul 2003; 23: 6914. Jin-Hun Jung, J. Biol. Chem., Dec 2005; 280: 40025 - 40031. Guo-Lei Zhou, Mol. Cell. Biol., Nov 2003; 23: 8058 - 8069.