Rabbit Polyclonal Antibody to GR (Ab-211)

Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression.Zhen Wang, Mol. Endocrinol., Mar 2007; 21: 625 - 634.Aaron L. Miller, Mol. Endocrinol., Jun 2005; 19: 1569 - 1583.Paul J. LeBlanc, J. Physiol., Jun 2004; 557: 559 - 570.Jos篓娄 Xavier-Neto, Hypertension, Jul 1999; 34: 31.