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Gel: 8%SDS-PAGELane1: Hela cell lysateLane2: 231 cell lysate Lane3: 293T cell lysateLysates: 40 ug per lanePrimary antibody: 1/550 dilutionSecondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilutionExposure time: 10 seconds

Rabbit Polyclonal Antibody to PIWIL4

货号：
P41617
别名：
Piwi-like RNA-mediated gene silencing 4, HIWI2; MIWI2
产品上架时间：
2024-01-01
应用：
WB
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
Q7Z3Z4
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥1980

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Rabbit Polyclonal Antibody to PIWIL4

Description
PIWIL4 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells. Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates with secondary piRNAs antisense and PIWIL2/MILI is required for such association.

Description

PIWIL4 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells. Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates with secondary piRNAs antisense and PIWIL2/MILI is required for such association.

Specification
Aliases	Piwi-like RNA-mediated gene silencing 4, HIWI2; MIWI2
Entrez GeneID	143689;
Swissprot	Q7Z3Z4
WB Predicted band size	97kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Fusion protein corresponding to a region derived from 546-838 amino acids of human piwi-like RNA-mediated gene silencing 4
Formulation	Purified antibody in PBS with 0.05% sodium azide.