Rabbit Polyclonal Antibody to CCR5(CD195)

Description
Receptor for a number of inflammatory CC-chemokines including MIP-1-a, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.

References
Samson M., Labbe O., Mollereau C. Biochemistry 35:3362-3367(1996)Raport C.J., Gosling J., Schweichart V.L. J. Biol. Chem. 271:17161-17166(1996) Combadiere C., Ahuja S.K., Tiffany H.L., Murphy P.M.J. Leukoc. Biol. 60:147-152(1996)

Specification
Aliases	CKR5; CD195; CKR-5
Entrez GeneID	1234;
Swissprot	P51681
WB Predicted band size	41kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Peptide sequence around aa.11~15(D-I-N-Y-Y) derived from Human CCR5(CD195).
Formulation	Purified antibody in PBS with 0.05% sodium azide.

Application
WB	1/500-1/1000