Rabbit Polyclonal Antibody to WASP

Description
Effector protein for Rho-type GTPases. Regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function. Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria.

References
Kolluri R., Tolias K.F., Carpenter C.L., Rosen F.S. Proc. Natl. Acad. Sci. U.S.A. 93:5615-5618(1996) Ramesh N., Anton I.M., Hartwig J.H., Geha R.S. Proc. Natl. Acad. Sci. U.S.A. 94:14671-14676(1997)Cory G.O.C., Cramer R., Blanchoin L., Ridley A.J. Mol. Cell 11:1229-1239(2003)

Specification
Aliases	THC; THC1; IMD2
Entrez GeneID	7454;
Swissprot	P42768
WB Predicted band size	53kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around aa.289~293 (L-I-Y-D-F) derived from Human WASP.
Formulation	Purified antibody in PBS with 0.05% sodium azide.

Application
WB	1/500-1/1000