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Rabbit Polyclonal Antibody to c-Cbl(Ab-700)

Western blot analysis of extracts from Hela and HT29 cells using c-Cbl(Ab-700) Antibody P41567.

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using c-Cbl(Ab-700) Antibody P41567(left) or the same antibody preincubated with blocking peptide(right).

Rabbit Polyclonal Antibody to c-Cbl(Ab-700)

货号：
P41567
别名：
Signal transduction protein CBL; Proto-oncogene c-CBL; Casitas B-lineage lymphoma proto-oncogene; RING finger protein 55;
产品上架时间：
2024-01-01
应用：
WB,IHC
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
P22681
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥1980

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Rabbit Polyclonal Antibody to c-Cbl(Ab-700)

Description
Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.

Description

Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.

References
Blake, T.J. et al. (1991) Oncogene 6, 653-657.Thien, C.B. and Langdon, W.Y. (1998) Immunol. Cell Biol. 76, 473-482.Kamei, T. et al. (2000) Int. J. Oncol. 17, 335-339.Hunter, C. et al. (1999) J. Biol. Chem. 274, 2097-2106.

Specification
Aliases	Signal transduction protein CBL; Proto-oncogene c-CBL; Casitas B-lineage lymphoma proto-oncogene; RING finger protein 55;
Entrez GeneID	867;
Swissprot	P22681
WB Predicted band size	120kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Peptide sequence around aa. 698~702 (T-E-Y-M-T) derived from Human c-Cbl.
Formulation	Purified antibody in PBS with 0.05% sodium azide.