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Western blot analysis of extracts from JK cells using syk(Ab-323) Antibody P41564.
Immunofluorescence staining of methanol-fixed Hela cells using syk(Ab-323) Antibody P41564.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using syk(Ab-323) Antibody P41564(left) or the same antibody preincubated with blocking peptide(right).

Rabbit Polyclonal Antibody to syk(Ab-323)

  • 货号:

    P41564
  • 别名:

    Spleen tyrosine kinase
  • 产品上架时间:

    2024-01-01
  • 应用:

    WB,IHC,IF
  • 反应种属:

    Human
  • 抗体类型:

    Primary antibody
  • Swissprot:

    P43405
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥1980

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Rabbit Polyclonal Antibody to syk(Ab-323)

Description

Positive effector of BCR-stimulated responses. Couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-348 and Tyr-352. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion

References

Zhang, J. et al. (2000) J. Biol. Chem. 275, 35442-35447.Turner, M. et al. (2000) Immunol. Today 21, 148-154.Decker, M. et al. (1998) J. Biol. Chem. 273, 8867-8874.Law, C.L. et al. (1996) Mol. Cell. Biol. 16, 1305-1315.

Specification

Aliases Spleen tyrosine kinase
Entrez GeneID 6850;
Swissprot P43405
WB Predicted band size 72kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Peptide sequence around aa. 321~325 (N-P-Y-E-P) derived from Human syk.
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

WB 1/500-1/1000
IHC 1/50-1/100
IF 1/100-1/200