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Western blot analysis of extracts from HT29 and Hela cells using FAK(Ab-576/577) Antibody P41563.

Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using FAK(Ab-576/577) Antibody P41563(left) or the same antibody preincubated with blocking peptide(right).

Rabbit Polyclonal Antibody to FAK(Ab-576/577)

货号：
P41563
别名：
FADK 1; FAK1; PTK2
产品上架时间：
2024-01-01
应用：
WB,IHC
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
Q05397
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥1980

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Rabbit Polyclonal Antibody to FAK(Ab-576/577)

Description
Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.

Description

Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.

References
Parsons, J.T. et al. (2000) Oncogene 19, 5606-5613.Schaller, M.D. et al. (1994) Mol. Cell. Biol. 14, 1680-1688.Chen, H.C. et al. (1996) J. Biol. Chem. 271, 26329-26334.Calalb, M.B. et al. (1995) Mol. Cell. Biol. 15, 954-963.

Specification
Aliases	FADK 1; FAK1; PTK2
Entrez GeneID	5747;
Swissprot	Q05397
WB Predicted band size	125kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around aa.574~578/575~579 (T-Y-Y-K-A) derived from Human FAK.
Formulation	Purified antibody in PBS with 0.05% sodium azide.