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Western blot analysis of extracts from Hela cells using STAT2(Ab-690) Antibody P41556 and the same antibody preincubated with blocking peptide.

Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using STAT2(Ab-690) Antibody P41556(left) or the same antibody preincubated with blocking peptide(right).

Rabbit Polyclonal Antibody to STAT2(Ab-690)

货号：
P41556
别名：
P113; ISGF-3; STAT113
产品上架时间：
2024-01-01
应用：
WB,IHC
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
P52630
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥1980

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Rabbit Polyclonal Antibody to STAT2(Ab-690)

Description
STAT2 encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-a response by adenovirus.

Description

STAT2 encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-a response by adenovirus.

References
Fu, X. et al. (1992) Biochemistry 89, 7840-7843.Park, C. et al. (2000) Immunity 13, 795-804.Horvath, C. et al. (1996) Molecular and Cellular Biology 16, 6957-6964.Improta, T. et al. (1994) Proc. Natl. Acad. Sci. USA 91, 4776-4780.

Specification
Aliases	P113; ISGF-3; STAT113
Entrez GeneID	6773;
Swissprot	P52630
WB Predicted band size	113kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Peptide sequence around aa.688~692 (R-K-Y-L-K) derived from Human STAT2.
Formulation	Purified antibody in PBS with 0.05% sodium azide.