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Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)

Immunofluorescence analysis of Hela cells using NR1H2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)

Flow cytometric analysis of A375 cells using NR1H2 mouse mAb (green) and negative control (red).

Flow cytometric analysis of Hela cells using NR1H2 mouse mAb (green) and negative control (red).

Flow cytometric analysis of Raji cells using NR1H2 mouse mAb (green) and negative control (red).

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Mouse Monoclonal Antibody to NR1H2

货号：
32194
别名：
NER; UNR; LXRB; LXR-b; NER-I; RIP15
产品上架时间：
2024-01-01
应用：
IF,FCM
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
P55055
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Mouse Monoclonal Antibody to NR1H2

Description
The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).

Description

The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).

References
1，J Cell Mol Med. 2019 Feb;23(2):789-797. 2,Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Sep;1863(9):968-979.

Specification
Aliases	NER; UNR; LXRB; LXR-b; NER-I; RIP15
Entrez GeneID	7376
Swissprot	P55055
clone	5C11D3
WB Predicted band size	51kDa
Host/Isotype	Mouse IgG2b
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human NR1H2 (AA:1-200) expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide