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Western blot analysis of extracts from HUVEC and 293 cells using Keratin 8(Ab-74) Antibody P41493.

Immunofluorescence staining of methanol-fixed Hela cells using Keratin 8(Ab-74) Antibody P41493.

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Keratin 8(Ab-74) Antibody P41493(left) or the same antibody preincubated with blocking peptide(right).

Rabbit Polyclonal Antibody to Keratin 8(Ab-74)

货号：
P41493
别名：
CK 8; CK8; CYK8; Cytokeratin endo A; K8
产品上架时间：
2024-01-01
应用：
WB,IHC,IF
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
P05787
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥1980

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Rabbit Polyclonal Antibody to Keratin 8(Ab-74)

Description
Keratin 8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis.

Description

Keratin 8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis.

References
Nakamichi I, et al. (2002) Mol Biol Cell; 13(10): 3441-3451.Prochasson P, et al. (2002) Nucleic Acids Res; 30(15): 3312-3322.Pankov R, et al. (1994) Proc Natl Acad Sci U S A; 91(3): 873-877.Thorey IS, et al. (1993) Mol Cell Biol; 13(11): 6742-6751.

Specification
Aliases	CK 8; CK8; CYK8; Cytokeratin endo A; K8
Entrez GeneID	3856;
Swissprot	P05787
WB Predicted band size	55kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Peptide sequence around aa.72~76 (L-L-S-P-L) derived from Human Keratin 8 (CK8).
Formulation	Purified antibody in PBS with 0.05% sodium azide.