Rabbit Polyclonal Antibody to IGF-1R(Ab-1280)

Description
This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1.

References
Adams, T.E. et al. (2000) Cell. Mol. Life Sci. 57, 1050-1093Baserga, R. et al. (2000) Oncogene 19, 5574-5581Scheidegger, K.J. et al. (2000) J. Biol. Chem. 275, 38921-38928.O'Connor R, et al. Mol Cell Biol 1997 Jan; 17(1): 427-35

Specification
Aliases	Insulin-like growth factor I receptor
Entrez GeneID	3480;
Swissprot	P08069
WB Predicted band size	200 95 kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Peptide sequence around aa. 1278~1282 (S-F-Y-Y-S ) derived from Human IGF-1R .
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Application
WB	1/500-1/1000
IHC	1/50-1/100