Rabbit Polyclonal Antibody to MEK1(Ab-291)

Description
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases.

References
Kevin D. Burroughs, et,al. (2003) Mol. Cancer Res ; 1: 312. Michael J. Piatelli, et,al. (2002) J. Biol. Chem ; 277: 12144 - 12150. Margaret M. Morgan, et,al. (2001) J. Immunol ; 167: 5708. Herbert Schramek, et,al. (2003) Am J Physiol Cell Physiol, ; 285: C652 - C661.

Specification
Aliases	ERK activator kinase 1; MAP kinase kinase 1; MAP2K1; MAPK/ERK kinase 1; MAPKK 1
Entrez GeneID	5604;
Swissprot	Q02750
WB Predicted band size	45kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around aa. 289~293 (P-R-T-P-G) derived from Human MEK1.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Application
WB	1/500-1/1000
IHC	1/50-1/100