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Western blot analysis of extracts from Mouse brain tissue and C6 cells using Merlin(Ab-518) Antibody P41453.

Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using Merlin(Ab-518) Antibody P41453(left) or the same antibody preincubated with blocking peptide(right).

Rabbit Polyclonal Antibody to Merlin(Ab-518)

货号：
P41453
别名：
MERL; NF2; Neurofibromin 2; SCH; Schwannomerlin
产品上架时间：
2024-01-01
应用：
WB,IHC
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
P35240
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥1980

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Rabbit Polyclonal Antibody to Merlin(Ab-518)

Description
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity.

Description

Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity.

References
Guang-Hui Xiao, et al. (2005) Mol. Cell. Biol ; 25: 2384 - 2394. Hi-Su Yang, et al. (2006) Cancer Res ; 66: 2708 - 2715. R Bohni, et al. (1994) J. Biol. Chem ; 269: 14541 - 14545. Adam J. Ratner, et al. (2001) J. Biol. Chem ; 276: 19267 - 19275.

Specification
Aliases	MERL; NF2; Neurofibromin 2; SCH; Schwannomerlin
Entrez GeneID	4771;
Swissprot	P35240
WB Predicted band size	69kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around aa.516~520 (R-L-S-M-E) derived from Human Merlin.
Formulation	Purified antibody in PBS with 0.05% sodium azide.