Rabbit Polyclonal Antibody to IRS-1(Ab-636)

Description
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit

References
Ozes ON, et al. (2001) Proc Natl Acad Sci U S A; 98(8): 4640-4645Tzatsos A, et al. (2006) Mol Cell Biol; 26(1): 63-76Kadowaki T, et al. (2000) J Clin Invest; 106(4): 459-465Ozes ON, et al. (2001) Proc Natl Acad Sci U S A; 98(8): 4640-4645Szanto I, et al. (2000) Proc Natl Acad Sci U S A; 97(5): 2355-2360

Specification
Aliases	IRS-1; IRS1;
Entrez GeneID	3667;
Swissprot	P35568
WB Predicted band size	180kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around aa.634~638 (P-M-S-P-K) derived from Human IRS-1.
Formulation	Purified antibody in PBS with 0.05% sodium azide.

Application
WB	1/500-1/1000
IHC	1/50-1/100
IF	1/100-1/200