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Western blot analysis of extracts from 293 and HepG2 cells using 4E-BP1 (Ab-46) Antibody P41419.

Immunofluorescence staining of methanol-fixed Hela cells using 4E-BP1 (Ab-46) Antibody P41419.

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using4E-BP1 (Ab-46) Antibody P41419(left) or the same antibody preincubated with blocking peptide(right).

Rabbit Polyclonal Antibody to 4E-BP1(Ab-46)

货号：
P41419
别名：
EIF4EBP1; PHAS-1;
产品上架时间：
2024-01-01
应用：
WB,IHC,IF
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
Q13541
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥1980

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Rabbit Polyclonal Antibody to 4E-BP1(Ab-46)

Description
4E-BP1 encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.

Description

4E-BP1 encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.

References
Gingras AC, et al. (1998) Genes Dev 12(4): 502-513. Brugarolas J, et al. (2004) Genes Dev 18(23): 2893-2904. Kumar V, et al. (2000) EMBO J 19(5): 1087-1097. Moody CA, et al. (2005) J Virol 79(9): 5499-5506. Burnett PE, et al. (1998) Proc Natl Acad Sci U S A 95(4): 1432-1437.

Specification
Aliases	EIF4EBP1; PHAS-1;
Entrez GeneID	1978;
Swissprot	Q13541
WB Predicted band size	18kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around aa.44~48 (S-T-T-P-G) derived from Human 4E-BP1.
Formulation	Purified antibody in PBS with 0.05% sodium azide.