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Rabbit Polyclonal Antibody to Paxillin(Ab-31)

Western blot analysis of extracts from 293 cells using Paxillin(Ab-31) Antibody P41403.

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Paxillin(Ab-31) Antibody P41403(left) or the same antibody preincubated with blocking peptide(right).

Rabbit Polyclonal Antibody to Paxillin(Ab-31)

货号：
P41403
别名：
PAXI; PXN;
产品上架时间：
2024-01-01
应用：
WB,IHC
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
P49023
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥1980

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Rabbit Polyclonal Antibody to Paxillin(Ab-31)

Description
An antiphosphotyrosine antibody was used to identify proteins that are phosphorylated in Rous sarcoma virus-transformed chick embryo fibroblasts, and a 76-kD protein was obtained that localizes to focal adhesions at the ends of actin-containing stress fibers in nontransformed cells (Ref.1). This protein was purified from chicken gizzard smooth muscle, and was named Pxn (Paxillin) ('paxillus' means 'small stake' or 'peg' in Latin) as a protein tethered to the membrane at focal adhesions

Description

An antiphosphotyrosine antibody was used to identify proteins that are phosphorylated in Rous sarcoma virus-transformed chick embryo fibroblasts, and a 76-kD protein was obtained that localizes to focal adhesions at the ends of actin-containing stress fibers in nontransformed cells (Ref.1). This protein was purified from chicken gizzard smooth muscle, and was named Pxn (Paxillin) ('paxillus' means 'small stake' or 'peg' in Latin) as a protein tethered to the membrane at focal adhesions

References
Davidson D, et al. (2001) EMBO J; 20(13): 3414-3426 Kook S, et al. (2000) Mol Biol Cell; 11(3): 929-939 Fleming I, et al. (1999) Proc Natl Acad Sci U S A; 96(3): 1123-1128 Goldberg MB, et al. (2001) Microbiol Mol Biol Rev; 65(4): 595-626 Thomas JT, et al. (1999) Proc Natl Acad Sci U S A; 96(15): 8449-8454

Specification
Aliases	PAXI; PXN;
Entrez GeneID	5829;
Swissprot	P49023
WB Predicted band size	68kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Peptide sequence around aa.29~33 (T-P-Y-S-Y) derived from Human Paxillin.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.