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Rabbit Polyclonal Antibody to PKCth(Ab-695)

Western blot analysis of extracts from HT29 cells using PKCth(Ab-695) Antibody P41391 and the same antibody preincubated with blocking peptide.

Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using PKCth(Ab-695) Antibody P41391(left) or the same antibody preincubated with blocking peptide(right).

Rabbit Polyclonal Antibody to PKCth(Ab-695)

货号：
P41391
别名：
KPCT; PKC-theta; PKCQ; PRKCQ; PRKCT
产品上架时间：
2024-01-01
应用：
WB,IHC
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
Q04759
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥1980

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Rabbit Polyclonal Antibody to PKCth(Ab-695)

Description
This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. Essential for T-cell receptor (TCR)-mediated T-cell activation, but is dispensable during TCR-dependent thymocyte development. Links the TCR signaling complex to the activation of NF-kappa-B in mature T lymphocytes. Required for interleukin-2 (IL2) production. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.

Description

This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. Essential for T-cell receptor (TCR)-mediated T-cell activation, but is dispensable during TCR-dependent thymocyte development. Links the TCR signaling complex to the activation of NF-kappa-B in mature T lymphocytes. Required for interleukin-2 (IL2) production. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.

References
Xu ZB, et al.(2004) J Biol Chem 279:50401-50409Thebault S, et al. (2004) Mol Immunol 40: 931-942

Specification
Aliases	KPCT; PKC-theta; PKCQ; PRKCQ; PRKCT
Entrez GeneID	5588;
Swissprot	Q04759
WB Predicted band size	80kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Peptide sequence around aa.693~697 (N-F-S-F-M) derived from Human PKCth.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.