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Rabbit Polyclonal Antibody to IkB-a(Ab-42)

Western blot analysis of extracts from 293 and THP1 cells using IkB-a(Ab-42) Antibody P41386.

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using IkB-a(Ab-42) Antibody P41386(left) or the same antibody preincubated with blocking peptide(right).

Rabbit Polyclonal Antibody to IkB-a(Ab-42)

货号：
P41386
别名：
I-kappa-B-alpha; IKBA; NF-kappaB inhibitor alpha; NFKBI; NFKBIA
产品上架时间：
2024-01-01
应用：
WB,IHC
反应种属：
Human,Mouse
抗体类型：
Primary antibody
Swissprot：
P25963
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥1980

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Rabbit Polyclonal Antibody to IkB-a(Ab-42)

Description
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to tranlocate to the nucleus and activate transcription.

References
B

Specification
Aliases	I-kappa-B-alpha; IKBA; NF-kappaB inhibitor alpha; NFKBI; NFKBIA
Entrez GeneID	4792;
Swissprot	P25963
WB Predicted band size	39kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Peptide sequence around aa. 40~44 (E-E-Y-E-Q) derived from Human IkB-a.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.