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Rabbit Polyclonal Antibody to Zap-70(Ab-493)

Western blot analysis of extracts from HL60 cells using Zap-70(Ab-493) Antibody P41384.

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Zap-70(Ab-493) Antibody P41384(left) or the same antibody preincubated with blocking peptide(right).

Rabbit Polyclonal Antibody to Zap-70(Ab-493)

货号：
P41384
别名：
70 kDa zeta-associated protein; SRK; Syk-related tyrosine kinase; ZA70; ZAP-70
产品上架时间：
2024-01-01
应用：
WB,IHC
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
P43403
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥1980

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Rabbit Polyclonal Antibody to Zap-70(Ab-493)

Description
ZAP70 is a 70-kD tyrosine phosphoprotein that associates with the zeta chain and undergoes tyrosine phosphorylation following TCR stimulation. The ZAP70 gene is expressed in T- and natural KILLER cells. Protein-Tyrosine Kinases (PTKs) play an integral role in T-cell activation. Stimulation of the T-cell antigen receptor results in tyrosine phosphorylation of a number of cellular substrates. One of these is the TCR-zeta chain, which can mediate the transduction of extracellular stimuli into cellular effector functions

Description

ZAP70 is a 70-kD tyrosine phosphoprotein that associates with the zeta chain and undergoes tyrosine phosphorylation following TCR stimulation. The ZAP70 gene is expressed in T- and natural KILLER cells. Protein-Tyrosine Kinases (PTKs) play an integral role in T-cell activation. Stimulation of the T-cell antigen receptor results in tyrosine phosphorylation of a number of cellular substrates. One of these is the TCR-zeta chain, which can mediate the transduction of extracellular stimuli into cellular effector functions

References
Chan AC, et al. (1995) EMBO J; 14(11): 2499-2508Kong G, et al. (1996) Mol Cell Biol; 16(9): 5026-5035Salomon AR, et al. (2003)Proc Natl Acad Sci U S A; 100(2): 443-448

Specification
Aliases	70 kDa zeta-associated protein; SRK; Syk-related tyrosine kinase; ZA70; ZAP-70
Entrez GeneID	7535;
Swissprot	P43403
WB Predicted band size	70kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around aa.491~495 (S-Y-Y-T-A) derived from Human ZAP70.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.