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Western blot analysis of extracts from HL60 cells using Zap-70(Ab-319) Antibody P41383.

Immunohistochemical analysis of paraffin-embedded human tonsil tissue using Zap-70(Ab-319) Antibody P41383(left) or the same antibody preincubated with blocking peptide(right).

Rabbit Polyclonal Antibody to Zap-70(Ab-319)

货号：
P41383
别名：
70 kDa zeta-associated protein; SRK; Syk-related tyrosine kinase; ZA70; ZAP-70
产品上架时间：
2024-01-01
应用：
WB,IHC
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
P43403
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥1980

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Rabbit Polyclonal Antibody to Zap-70(Ab-319)

Description
ZAP70 is a 70-kD tyrosine phosphoprotein that associates with the zeta chain and undergoes tyrosine phosphorylation following TCR stimulation. The ZAP70 gene is expressed in T- and natural KILLER cells. Protein-Tyrosine Kinases (PTKs) play an integral role in T-cell activation. Stimulation of the T-cell antigen receptor results in tyrosine phosphorylation of a number of cellular substrates. One of these is the TCR-zeta chain, which can mediate the transduction of extracellular stimuli into cellular effector functions

Description

ZAP70 is a 70-kD tyrosine phosphoprotein that associates with the zeta chain and undergoes tyrosine phosphorylation following TCR stimulation. The ZAP70 gene is expressed in T- and natural KILLER cells. Protein-Tyrosine Kinases (PTKs) play an integral role in T-cell activation. Stimulation of the T-cell antigen receptor results in tyrosine phosphorylation of a number of cellular substrates. One of these is the TCR-zeta chain, which can mediate the transduction of extracellular stimuli into cellular effector functions

References
Salomon AR, et al. (2003) Proc Natl Acad Sci U S A; 100(2): 443-448 Ku GM, et al. (2001) EMBO J; 20(3): 457-465 Tang J, et al. (1999) Proc Natl Acad Sci U S A; 96(17): 9775-9780 Zhao Q, et al. (1996) Mol Cell Biol; 16(12): 6765-6774 Williams BL, et al. (1999) EMBO J; 18(7): 1832-1844 Adjali O, et al. (2005) J Clin Invest; 115(8): 2287-2295.

Specification
Aliases	70 kDa zeta-associated protein; SRK; Syk-related tyrosine kinase; ZA70; ZAP-70
Entrez GeneID	7535;
Swissprot	P43403
WB Predicted band size	70kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around aa.317~321 (S-P-Y-S-D) derived from Human ZAP70.
Formulation	Purified antibody in PBS with 0.05% sodium azide.