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Western blot analysis of extracts from MCF-7 and Hela cells using PAK1/PAK2/PAK3(Ab-423/402/421) Antibody P41379.

Immunofluorescence staining of methanol-fixed Hela cells using PAK1/PAK2/PAK3(Ab-423/402/421) Antibody P41379.

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using PAK1/PAK2/PAK3(Ab-423/402/421) Antibody P41379(left) or the same antibody preincubated with blocking peptide(right).

Rabbit Polyclonal Antibody to PAK1/PAK2/PAK3(Ab-423/402/421)

货号：
P41379
别名：
p21-activated kinase 1; PAK-1; p65-PAK; Alpha-PAK;
产品上架时间：
2024-01-01
应用：
WB,IHC,IF
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
Q13153
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥1980

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Rabbit Polyclonal Antibody to PAK1/PAK2/PAK3(Ab-423/402/421)

Description
The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.

Description

The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.

References
Parsons M, et al. (2005) Mol Cell Biol ; 25:1680-1695.Jung JH, et al. (2005) J Biol Chem; 280:40025-40031.Lampugnani MG, et al. (2002) Mol Biol Cell ; 13: 1175-1189Wang RA, et al. (2002) EMBO J; 21: 5437 - 5447.

Specification
Aliases	p21-activated kinase 1; PAK-1; p65-PAK; Alpha-PAK;
Entrez GeneID	5058;
Swissprot	Q13153
WB Predicted band size	61-67 (PAK2) 68-74 (PAK1/3)kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around aa.421~425/400~404/419~423 (R-S-T-M-V) derived from Human PAK1/PAK2/PAK3.
Formulation	Purified antibody in PBS with 0.05% sodium azide.