Rabbit Polyclonal Antibody to p21Cip1(Ab-145)

Description
May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.

References
Ocker M Int,et al. (2007)J Biochem Cell Biol. 39(7-8):1367-74.Dangi S, et al.(2006)Cell Prolif. 39(4):261-79.Chen J,et al.(2006)Am J Physiol Heart Circ Physiol. 290(4):H1575-86

Specification
Aliases	CAP20; CDK-interacting protein 1; CDKN1; CDKN1A; CDN1A
Entrez GeneID	1026;
Swissprot	P38936
WB Predicted band size	21kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Peptide sequence around aa.143~147 (R-Q-T-S-M) derived from Human p21Cip1.
Formulation	Purified antibody in PBS with 0.05% sodium azide.

Application
WB	1/500-1/1000