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Western blot analysis of extracts from Hela cells using FAK(Ab-925) Antibody P41362 and the same antibody preincubated with blocking peptide.

Immunofluorescence staining of methanol-fixed Hela cells using FAK(Ab-925) Antibody P41362.

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using FAK(Ab-925) Antibody P41362(left) or the same antibody preincubated with blocking peptide(right).

Rabbit Polyclonal Antibody to FAK(Ab-925)

货号：
P41362
别名：
FADK 1; FAK1; PTK2
产品上架时间：
2024-01-01
应用：
WB,IHC,IF
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
Q05397
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥1980

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Rabbit Polyclonal Antibody to FAK(Ab-925)

Description
Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.

Description

Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.

References
Sanders MA, et al. (2005) J Biol Chem; 280(25): 23516-22.Cherubini A, et al. (2005) Mol Biol Cell; 16(6): 2972-83.Toriumi Y, et al. (2003) FEBS Lett; 553(3): 419-22.Shi Q, et al. (2003) Mol Biol Cell; 14(10): 4306-15.

Specification
Aliases	FADK 1; FAK1; PTK2
Entrez GeneID	5747;
Swissprot	Q05397
WB Predicted band size	125kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around aa.923~927 (K-V-Y-E-N) derived from Human FAK.
Formulation	Purified antibody in PBS with 0.05% sodium azide.