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Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using TYK2(Ab-1054) Antibody P41337(left) or the same antibody preincubated with blocking peptide(right).

Rabbit Polyclonal Antibody to TYK2(Ab-1054)

货号：
P41337
别名：
tyrosine kinase 2; JTK1;
产品上架时间：
2024-01-01
应用：
IHC
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
P29597
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥1980

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Rabbit Polyclonal Antibody to TYK2(Ab-1054)

Description
TYK2 encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.

Description

TYK2 encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.

References
Zheng H, et al. (2005) Mol Cell Proteomics. 4(6):721-730. Gauzzi MC, et al. (1996) J Biol Chem. 271(34): 20494-20500.

Specification
Aliases	tyrosine kinase 2; JTK1;
Entrez GeneID	7297;
Swissprot	P29597
WB Predicted band size	140kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around aa.1052~1056 (H-E-Y-Y-R) derived from Human TYK2.
Formulation	Purified antibody in PBS with 0.05% sodium azide.