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Western blot analysis of extracts from MDA cells using MKK3(Ab-189) Antibody P41335.

Immunofluorescence staining of methanol-fixed Hela cells using MKK3(Ab-189) Antibody P41335.

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using MKK3(Ab-189) Antibody P41335(left) or the same antibody preincubated with blocking peptide(right).

Rabbit Polyclonal Antibody to MKK3(Ab-189)

货号：
P41335
别名：
MAP kinase kinase 3; MAP2K3; MAPK/ERK kinase 3; MAPKK 3; MEK3
产品上架时间：
2024-01-01
应用：
WB,IHC,IF
反应种属：
Human,Mouse
抗体类型：
Primary antibody
Swissprot：
P46734
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥1980

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Rabbit Polyclonal Antibody to MKK3(Ab-189)

Description
MEK3 belongs to MAPKK family. This kinase is activated by mitogenic and environmental stress, and participates in the MAPK-mediated signaling cascade. It phosphorylates and thus activates p38. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of Ras oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of p38, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis.

Description

MEK3 belongs to MAPKK family. This kinase is activated by mitogenic and environmental stress, and participates in the MAPK-mediated signaling cascade. It phosphorylates and thus activates p38. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of Ras oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of p38, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis.

References
Wang W, et al. (2002) Mol Cell Biol ; 22(10): 3389-403. Raingeaud J, et al. (1996) Mol Cell Biol; 16(3): 1247-55.

Specification
Aliases	MAP kinase kinase 3; MAP2K3; MAPK/ERK kinase 3; MAPKK 3; MEK3
Entrez GeneID	5606;
Swissprot	P46734
WB Predicted band size	40kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Peptide sequence around aa.187~191 (V-D-S-V-A) derived from Human MKK3.
Formulation	Purified antibody in PBS with 0.05% sodium azide.