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Rabbit Polyclonal Antibody to FAK(Ab-861)

Western blot analysis of extracts from HT29, Hela and 293 cells using FAK(Ab-861) Antibody P41303.

Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using FAK(Ab-861) Antibody P41303(left) or the same antibody preincubated with blocking peptide(right).

Rabbit Polyclonal Antibody to FAK(Ab-861)

货号：
P41303
别名：
FADK 1; FAK1; PTK2
产品上架时间：
2024-01-01
应用：
WB,IHC
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
Q05397
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥1980

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Rabbit Polyclonal Antibody to FAK(Ab-861)

Description
Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.

Description

Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.

References
Shi Q, et al. (2003) Mol Biol Cell; 14(10): 4306-15.Vadlamudi RK, et al. (2003) FEBS Lett; 543(1-3): 76-80.Eliceiri BP, et al. (2002) J Cell Biol Apr 01; 157(1): 149-60.Abu-Ghazaleh R, (2001) et al. Biochem J; 360(Pt 1): 255-64.Slack JK, et al.(2001) Oncogene; 20(10): 1152-63.

Specification
Aliases	FADK 1; FAK1; PTK2
Entrez GeneID	5747;
Swissprot	Q05397
WB Predicted band size	125kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Peptide sequence around aa. 859~863 (H-I-Y-Q-P) derived from Human FAK.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.