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Western blot analysis of extracts from HT29 and HepG2 cells using BAD(Ab-136) Antibody P41291.

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using BAD(Ab-136) Antibody P41291(left) or the same antibody preincubated with blocking peptide(right).

Rabbit Polyclonal Antibody to BAD(Ab-136)

货号：
P41291
别名：
Bbc2
产品上架时间：
2024-01-01
应用：
WB,IHC
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
Q61337
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥1980

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Rabbit Polyclonal Antibody to BAD(Ab-136)

Description
The protein encoded by BAD gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.

Description

The protein encoded by BAD gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.

References
Wang XQ, et al. (2001). J Biol Chem.276 (48): 44504-44511. Lee YI, et al. (2001). J Biol Chem.276 (20): 16969-16977. Maiti D, et al. (2001). J Biol Chem.276 (1): 329-333.

Specification
Aliases	Bbc2
Entrez GeneID	12015;
Swissprot	Q61337
WB Predicted band size	23kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around aa.134~138 (S-R-S-A-P) derived from Mouse BAD.
Formulation	Purified antibody in PBS with 0.05% sodium azide.