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Western blot analysis of extracts from Jurkat cells using p95/NBS1(Ab-343) Antibody P41286 and the same antibody preincubated with blocking peptide.

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p95/NBS1(Ab-343) Antibody P41286(left) or the same antibody preincubated with blocking peptide(right).

Rabbit Polyclonal Antibody to p95/NBS1(Ab-343)

货号：
P41286
别名：
NBN
产品上架时间：
2024-01-01
应用：
WB,IHC
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
O60934
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥1980

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Rabbit Polyclonal Antibody to p95/NBS1(Ab-343)

Description
Mutations in p95/NBS1 gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.

Description

Mutations in p95/NBS1 gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.

References
Hsu HL, et al (2005)Oncogene; 24(31): 4956-64.Falck J, et al. (2005) Nature; 434(7033): 605-11.Buscemi G, et al. (2004) Oncogene; 23(46): 7691-700.Beausoleil SA, et al. (2004) Proc Natl Acad Sci U S A; 101(33): 12130-5.

Specification
Aliases	NBN
Entrez GeneID	4683;
Swissprot	O60934
WB Predicted band size	95kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Peptide sequence around aa.341~345 (S-L-S-Q-G) derived from Human p95/NBS1.
Formulation	Purified antibody in PBS with 0.05% sodium azide.