Rabbit Polyclonal Antibody to CREB(Ab-133)

Description
This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Implicated in synchronization of circadian rhythmicity.

References
Xing J, et al. (1998) Mol Cell Biol 18(4): 1946-55.Tan Y, et al.( 1996) EMBO J; 15(17): 4629-42.Hao, M. et al. (1996) J. Biol. Chem. 271, 29380-29385.Mayo LD, et al. (2001) Biol Chem; 276(27): 25184-9.Lu, H. et al. (1997) Mol. Cell. Biol. 17, 5923-5934.

Specification
Aliases	CREB-1; CREB1;
Entrez GeneID	1385;
Swissprot	P16220
WB Predicted band size	43kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Peptide sequence around aa. 131~135 (R-P-S-Y-R) derived from Human CREB.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Application
WB	1/500-1/1000
IHC	1/50-1/100