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Western blot analysis of extracts from HT29 cells using NFkB-p105/p50(Ab-337) Antibody P41253 and the same antibody preincubated with blocking peptide.

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using NFkB-p105/p50(Ab-337) Antibody P41253(left) or the same antibody preincubated with blocking peptide(right).

Rabbit Polyclonal Antibody to NFkB-p105/p50(Ab-337)

货号：
P41253
别名：
DNA-binding factor KBF1; EBP-1; NF-kappa-B1 p84/NF-kappa-B1 p98; NFKB1; NFkB-p50
产品上架时间：
2024-01-01
应用：
WB,IHC
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
P19838
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥1980

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Rabbit Polyclonal Antibody to NFkB-p105/p50(Ab-337)

Description
NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively.

Description

NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively.

References
Hou S, et al. (2003) J Biol Chem. 278(46): 45994-45998.Baeuerle P A, et al. (1994) Annu Rev Immunol. 12:141-179.Baeuerle P A, et al. (1996) Cell 87:13-20.Haskill S, et al. (1991) Cell 65:1281-1289.

Specification
Aliases	DNA-binding factor KBF1; EBP-1; NF-kappa-B1 p84/NF-kappa-B1 p98; NFKB1; NFkB-p50
Entrez GeneID	4790;
Swissprot	P19838
WB Predicted band size	50 120 kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around aa.335~339 (R-K-S-D-L) derived from Human NFkB-p105.
Formulation	Purified antibody in PBS with 0.05% sodium azide.