Rabbit Polyclonal Antibody to Raf1(Ab-259)

Description
Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. Part of the Ras-dependent signaling pathway from receptors to the nucleus. Protects cells from apoptosis mediated by STK3.

References
Dougherty M K, et al. (2005) Mol Cell. 17(2): 215-224.Hekman M, et al. (2005) FEBS Lett. 579(2): 464-468.Avruch J,et al. (1994) Trends Biochem. Sci. 19, 279-283.Chong H, et al. (2001) EMBO J. 20, 3716-3727.King A J, et al. (1998) Nature. 396:180-183.Fabian J R, et al. (1993) Mol Cell Biol. 13: 7170-7179.

Specification
Aliases	C-RAF; C-Raf; CRAF
Entrez GeneID	5894;
Swissprot	P04049
WB Predicted band size	73kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around aa.257~261 (S-T-S-T-P) derived from Human RAF.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Application
WB	1/500-1/1000
IHC	1/50-1/100