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Immunofluorescence analysis of U2OS cell using Phospho-ESPL1-S1126 antibody. Blue: DAPI for nuclear staining.

Rabbit Polyclonal Antibody to ESPL1(Phospho-S1126/801)

  • 货号:

    P40770
  • 别名:

    ESP1; SEPA
  • 产品上架时间:

    2024-01-01
  • 应用:

    WB,IF
  • 反应种属:

    Human
  • 抗体类型:

    Primary antibody
  • Swissprot:

    Q14674
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Rabbit Polyclonal Antibody to ESPL1(Phospho-S1126/801)

Description

Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids.

Specification

Aliases ESP1; SEPA
Entrez GeneID 9700;
Swissprot Q14674
WB Predicted band size 233kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen A phospho specific peptide corresponding to residues surrounding S1126 of human ESPL1.
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

WB 1/500-1/2000
IF 1/20-1/100

For Reseach Only

Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation

#P40770