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Rabbit Polyclonal Antibody to Epo-R (Phospho-Tyr368)

Western blot analysis of extracts from K562 tissue using Epo-R (Phospho-Tyr368) antibody P40626.The lane on the right is treated with the antigen-specific peptide.

Rabbit Polyclonal Antibody to Epo-R (Phospho-Tyr368)

货号：
P40626
别名：
EPO R; EPO-R; epor;
产品上架时间：
2024-01-01
应用：
WB
反应种属：
Human,Mouse
抗体类型：
Primary antibody
Swissprot：
P19235
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Rabbit Polyclonal Antibody to Epo-R (Phospho-Tyr368)

Description
Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase. Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling.Funakoshi-Tago M, et al. (2010) J Biol Chem 285, 5296-307 Sulahian R, Cleaver O, Huang LJ (2009) Blood 113, 5287-97 Zhang YL, et al. (2009) Mol Cell 33, 266-74

Description

Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase. Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling.Funakoshi-Tago M, et al. (2010) J Biol Chem 285, 5296-307 Sulahian R, Cleaver O, Huang LJ (2009) Blood 113, 5287-97 Zhang YL, et al. (2009) Mol Cell 33, 266-74

Specification
Aliases	EPO R; EPO-R; epor;
Entrez GeneID	2057;
Swissprot	P19235
WB Predicted band size	55kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Peptide sequence around phosphorylation site of Tyrosine 368 (D-T-Y(p)-L-V) derived from Human Epo-R.
Formulation	Purified antibody in PBS with 0.05% sodium azide.